http://sklsgb.swu.edu.cn/cn/uploads/allimg/130106/2-130106105030G4.jpg
教授、博士生導(dǎo)師
重慶市百人計(jì)劃特聘教授
重慶市巴渝學(xué)者
簡歷：
從本科填起
1988.9-1992.7 西南農(nóng)業(yè)大學(xué) 學(xué)士
1992.9-1995.7 西南農(nóng)業(yè)大學(xué) 碩士
1995. 7-1997.9 山東省煙臺蠶種場 技術(shù)員
1997.9 -2000.7 西南農(nóng)業(yè)大學(xué) 博士
2000.7-2001.2 第四軍醫(yī)大學(xué) 博士后
2001.2 - 2005.7 美國俄亥俄醫(yī)學(xué)院 博士后
2005.7 -2009.5 美國俄亥俄醫(yī)科大學(xué) 助理教授
2009.5-2010.7 美國克利夫蘭醫(yī)學(xué)研究中心 項(xiàng)目專員
2010.1-2010.6 中美冠科生物技術(shù)公司腫瘤藥效學(xué)部 總監(jiān)
2010.6- 家蠶基因組生物學(xué)國家重點(diǎn)實(shí)驗(yàn)室 教授
主要科研領(lǐng)域與方向:
干細(xì)胞生物學(xué)、腫瘤生物學(xué)與轉(zhuǎn)化研究
科學(xué)成就：
申請者2010年5月回國前在美國從事多年干細(xì)胞生物學(xué)研究， 著重探討了腫瘤干細(xì)胞在腫瘤發(fā)生、形成上的機(jī)理，尋找腫瘤的特異性分子標(biāo)志，就腫瘤干細(xì)胞的分子標(biāo)記進(jìn)行了原創(chuàng)性工作，發(fā)現(xiàn)和闡明了在腫瘤發(fā)生過程中原癌基因N-myc對干細(xì)胞的作用機(jī)理。并系統(tǒng)論證了多梳族轉(zhuǎn)錄因子在神經(jīng)腫瘤干細(xì)胞的調(diào)控，為特異性阻斷此通路進(jìn)行優(yōu)化治療提供了可行性依據(jù)，為腫瘤的預(yù)后監(jiān)控提供了新的重要檢測指標(biāo)。
回國后建立了家蠶干細(xì)胞生物學(xué)實(shí)驗(yàn)室，獲得重慶市“百人計(jì)劃”和“巴渝學(xué)者”擇優(yōu)支持。以干細(xì)胞生物學(xué)作為家蠶基因組生物學(xué)國家重點(diǎn)實(shí)驗(yàn)室發(fā)展的重要支撐方向之一，著重研究家蠶各成體干細(xì)胞在變態(tài)發(fā)育的分子機(jī)制，開展家蠶組織、器官內(nèi)干細(xì)胞的識別、維持及其多向分化調(diào)控研究。以家蠶開展人類疾病的模型的研制，實(shí)現(xiàn)從昆蟲模型、到老鼠模型以及到人類疾病藥效的轉(zhuǎn)化研究。
近年在國內(nèi)外重要期刊發(fā)表30篇以上，SCI文章20篇，影響因子超過100分，被SCI源文章廣泛引用。主持和參加國內(nèi)973課題與美國NIH基金、美國癌癥研究協(xié)會重大科研項(xiàng)目多項(xiàng)。多次被相關(guān)國際學(xué)術(shù)會議選為執(zhí)行主席和特邀報(bào)告人，共計(jì)獲邀參加國際會議并做大會報(bào)告10次以上。并被多家雜志邀請為審稿人。
代表性論文：
- Mao L, Ding J, Zha Y, Yang L, McCarthy B, King W, Hongjuan Cui, Ding H. HOXC9 links cell cycle exit and neuronal differentiation and is a prognostic marker in neuroblastoma. Cancer Res., 2011 Jun 15;71(12):4314-24. Epub 2011 Apr 20.
- L Mao, J Ding, A Perdue, L Yang, Y Zha, M Ren, S Huang, Hongjuan Cui and H-F Ding, Cyclin E1 is a common target of BMI1 and MYCN and a prognostic marker for neuroblastoma progression. Oncogene (2011) 1–11.
- Gonit M, Zhang J, Salazar MD, Hongjuan Cui, Shatnawi A, Trumbly R, Ratnam M. Hormone depletion-insensitivity of prostate cancer cells is supported by the AR without binding to classical response elements. Mol Endocrinol. 2011 Apr;25(4):621-34. Epub 2011 Feb 17.
- Tai Li, Zhao-Bo Cui, Xiao-Xue Ke, Juan Tan, Fang-Fang Li, Ting Li, Xiang-Wei Wang, and Hong-Juan Cui. Essential Role for p53 and Caspase-9 in DNA Damaging Drug-Induced Apoptosis in Neuroblastoma IMR32 Cells. DNA and Cell Biology, 2011 Dec;30(12):1045-50 Epub 2011 may 25.
- Tai Li, Lin Wang, Xiao-xue Ke, Man Xu, Zhao-bo Cui, Hongjuan Cui, DNA damaging drugs-induced apoptosis sensitized by N-myc in neuroblastoma cells. Cell Biology International, (2012) 36, 331–337. Epub ahead of print, DOI 10.1042/CBI20110231.
- Zhichuan Li, Zhongbing Zhang, Joe X. Xie, Xin Li, Jiang Tian, Hongjuan Cui, Hanfei Ding, Joseph I. Shapiro and Zijian Xie. Na/K-ATPase mimetic pNaKtide inhibits the growth of human cancer cells. 2011, Journal of Biological Chemistry, J Biol Chem. 2011 Sep 16;286(37):32394-403. Epub 2011 Jul 22.
- Xiangwei Wang, Lunshan Xu, Jianhua Wan, Xueyang Gong, Kui Zhang, Liang Yi, Zhonghuai Xiang, Minhui Xu, Hongjuan Cui. Sonic Hedgehog pathway is essential for neuroblastoma cell proliferation and tumor growth. MCBI, DOI 10.1007/s11010-011-1222-6.
- Yang L, Hongjuan Cui, Wang Z, Zhang B, Ding J, Liu L, Ding HF. Loss of negative feedback control of nuclear factor-kappa B2 activity in lymphocytes leads to fatal lung inflammation. Am J pathol, 2010 Jun;176(6):2646-57. Epub 2010 Apr 2
- Yang H, Zhu L, Ebraheim NA, Liu X, Castillo S, Tang T, Liu J, Hongjuan Cui. 2009, Analysis of risk factors for recurrence after the resection of sacral chordoma combined with embolization. Spine J. 2009 Dec;9(12):972-80. Epub 2009 Oct 1.
- Ling Mao, Yuan-Peng Xia, Yu-Nan Zhou, Ruo-Lian Dai, Xue Yang, Shu-Jie Duan, Xian Qiao, Yuan-Wu Mei, Bo Hu and Hongjuan Cui, 2009 A critical role of Sonic Hedgehog signaling in maintaining the tumorigenicity of neuroblastoma cells [url=]Cancer Sci.[/url] 2009 Oct;100(10):1848-55. Epub 2009 Jun 26,.
- Goleeta Alam, Hongjuan Cui (co-principal author), Huilin Shi, Jane Ding, ling Mao, William A. Maltese, and Han-Fei Ding, MYCN promotes the expansion of Phox2B-positive neuronal progenitors to drive neuroblastoma development. [url=]Am J Pathol.[/url] 2009 Aug; 175(2):856-66. Epub 2009 Jul 16.
- Huilin Shi, Hongjuan Cui, Goleeta Alam, William Gunning, Andrea Nestor, David Giovannucci, Ming Zhang, Han-Fei Ding, 2008. Nestin expression defines both glial and neuronal progenitors in postnatal sympathetic ganglia, Journal of Comparative Neurology, 508: 867-878.
- Hongjuan Cui, Bo Hu, Tai Li, Jun Ma, Goleeta Alam, William T Gunning, and Han-Fei Ding, 2007. Bmi-1 is essential for the tumorigenicity of Neuroblastoma cells, American Journal of Pathology, 170 (4): 1370-1378.
- Hongjuan Cui, Jun Ma, Jane Ding, Tai Li, Goleeta Alam, and Han-Fei Ding, 2006, Bmi-1 regulates differentiation and clonogenic self-renewal of I-type neuroblastoma cells in a concentration-dependent manner, Journal of Biological Chemistry, 281 (45): 34696-34704.
- Hongjuan Cui, Tai Li, Han-Fei Ding, 2005, Linking of N-Myc to death receptor machinery in neuroblastoma cells, Journal of Biological Chemistry, 280: 9474-9481.
- Yongqing Wang, Hongjuan Cui (Co-principal author), Allen Schroering, Jane L. Ding, William S. lane, Gaël McGill, David E. Fisher and Han-Fei Ding. 2002. NF-ĸB2 p100 is a pro-apoptotic protein with anti-oncogenic function. Nature Cell Biology. 4(11): 888-93.
- Hongjuan Cui, Allen Schroering, and Han-Fei Ding. 2002. p53 mediated DNA damaging drug-induced apoptosis through a caspase-9-dependent pathway in Sh-SY5Y neuroblastoma cells. Molecular Cancer Therapeutics. 1: 679-686.
聯(lián)系地址： 400716，西南大學(xué) 家蠶基因組生物學(xué)國家重點(diǎn)實(shí)驗(yàn)室
電 話： 023-68251712
傳 真： 023-68251128
E-mail： hongjuan.cui@gmail.com
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