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杜宏武

教授生物科學與工程系副主任

辦公地點： 理化樓112

辦公電話： 62334497

電子郵件： hongwudu@ustb.edu.cn

本科課程： 《生物芯片》 《現代生物技術導論》 《生命科學導論》 《生物工程》 《專業前沿進展講座I》

科研方向： 生物制藥 臨床診斷試劑 藥物新靶點 生物芯片 功能蛋白質組學 系統生物學和轉化醫學

簡歷

北科大422引進人才、北京市科技新星、教育部新世紀優秀人才 2009年6月-2011年6月：斯坦福大學醫學院，Staff Scientist。 2007年1月-今：北京科技大學，系副主任，副教授，碩士生導師。 2000年10月-2005年11月：生物芯片國家工程研究中心，高級科學家、免疫技術部副主任。 2000年9月-2005年1月：清華大學醫學院，理學博士。 1997年9月-2000年7月：中國協和醫科大學（中國醫學科學院），理學碩士。 1993年9月-1997年7月：山東大學生命科學學院，理學本科。

科研業績

先后主持國家自然科學基金（3項），教育部重點/新世紀，科技部科技支撐等多項科研課題。

獲得獎勵/專利

北京市“科技新星” （2007）； 國家“科技奧運先進個人”（2008）； 美國斯坦福“HIMC杰出貢獻獎”（2011）； 生物芯片國家工程中心最高科研貢獻獎； 美國HIMC杰出研究特別貢獻獎； 世界反興奮劑機構臨床診斷試劑評比第一名。

代表性論文論著

1. X. Wang, P. Chen, J. Cui, C. Yang and Du H. Keratin 8 is a novel autoantigen of rheumatoid arthritis. Biochem Biophys Res Commun. (2015) 30390-9.

2. C.C. Whiting, J. Siebert, A.M. Newman, Du H, A.A. Alizadeh, J. Goronzy, C.M. Weyand, E. Krishnan, C.G. Fathman and H.T. Maecker. Large-Scale and Comprehensive Immune Profiling and Functional Analysis of Normal Human Aging. PLoS One. (2015) e133627.

3. J. Liang, W. Yang, X. Meng, P. Chen and Du H. Heterogeneous Nuclear Ribonucleoprotein A2/B1 as a Target Antigen in Han Chinese for BD Patients. Protein Pept Lett. (2015) 504-508.

4. Du H, G. Chen, Y. Bian, C. Xing, X. Ding, M. Zhu, Y. Xun, P. Chen, Y. Zhou and S. Li, Screening hybridomas for anabolic androgenic steroids by steroid analog antigen micro. Bioanalysis. (2015) 1201-1209.

5. Y. Xun, G. Chen and H. Du. Combinatorial Application of Multiple High-throughput Biotechnologies for the Study of Autoimmune Diseases. Current Pharmaceutical Analysis. (2015) 156-163.

6. L. Shi, P. Chen, Y. Xun, W. Yang, C. Yang, G. Chen and H. Du. Prohibitin as a novel autoantigen in rheumatoid arthritis. Central European Journal of Immunology. (2015) 78-82.

7. H. Du, L. Shi, P. Chen, W. Yang, Y. Xun, C. Yang, L. Zhao, Y. Zhou and G. Chen. Prohibitin is Involved in Patients with IgG4 Related Disease. PLoS One (2015) 10(5):e0125331.

8. P. Chen, W. Yang, Y. Tian, S. Sun, G. Chen, C. Zhang, F. Ma, Y. Xun, L. Shi and H. Du. Electron Transfer Flavoprotein Subunit Beta Is a Candidate Endothelial Cell Autoantigen in Behçet’s Disease. PLoS One. (2015) 10(4):e0124760.

9. P. Chen, H. Yan, Y. Tian, Y. Xun, L. Shi, R. Bao, H. Zhang, G. Chen, C. Yang, S. Sun, Y. Wang, L. Liu, Y. Zhou, C. Zhang, X. Wang, Y. Wen, Y. Bian and Du H. Annexin A2 as a target endothelial cell membrane autoantigen in Behcet's disease. Sci Rep. (2015) 8162.

10. P. Chen, L. Shi, Y. Jiang, Y. Ji, H. Yan, S. Sun, Y. Xun, G. Chen, X. Wang, W. Chen and Du H. Identification of heat shock protein 27 as a novel autoantigen of Behcet's disease. Biochem Biophys Res Commun. (2015) 456(4):866-71.

11. Z. Kang, X. Yan, L. Zhao, Q. Liao, K. Zhao, H. Du, X. Zhang, X. Zhang and Y. Zhang. Gold nanoparticle/ZnO nanorod hybrids for enhanced reactive oxygen species generation and photodynamic therapy. Nano Research. (2015) 1-11.

12. M. Zhu, Y. Zhou, L. Yang, L. Li, D. Qi, M. Bai, Y. Chen, Du H and Y. Bian. Synergistic Coupling of Fluorescent "Turn-Off" with Spectral Overlap Modulated FRET for Ratiometric Ag(+) Sensor. Inorg Chem. (2014) 12186-12190.

13. Du H, G. Chen, C. Yang, C. Li, Y. Xun, J. Liu, P. Chen and L. Shi. Multiple correlations of mRNA expression and protein abundance in human cytokine profile. Mol Biol Rep. (2014) 6985-6993.

14. Y. Xun, P. Chen, H. Yan, W. Yang, L. Shi, G. Chen and Du H. Identification of prohibitin as an antigen in Behcet's disease. Biochem Biophys Res Commun. (2014) 389-393.

15. L. Sun, J. Lin, Du H, C. Hu, Z. Huang, Z. Lv, C. Zheng, X. Shi, Y. Zhang and Z. Yang. Gender-specific DNA methylome analysis of a Han Chinese longevity population. Biomed Res Int. (2014) 396727.

16. H. Du, J. Liu, Y. Xun, J. Liang, S. Li and G. Chen. Determination of Deoxynivalenol, Zearalenone, Aflatoxin B1, and Ochratoxin by an Enzyme-Linked Immunosorbent Assay. Anal Lett. (2014) 1-9.

17. W. Wang, Y. Wen, L. Xu, Du H, Y. Zhou and X. Zhang. A selective release system based on dual-drug-loaded mesoporous silica for nanoparticle-assisted combination therapy. Chemistry. (2014) 7796-7802.

18. Y. Zhao, X. Yan, Z. Kang, X. Fang, X. Zheng, L. Zhao, H. Du and Y. Zhang. Zinc oxide nanowires-based electrochemical biosensor for L-lactic acid amperometric detection. Journal of Nanoparticle Research. (2014) 1-9.

19. L.L. Ritterhouse, R. Lu, H.B. Shah, J.M. Robertson, D.A. Fife, H.T. Maecker, Du H, C.G. Fathman, E.F. Chakravarty, R.H. Scofield, D.L. Kamen, J.M. Guthridge and J.A. James. Vitamin d deficiency in a multiethnic healthy control cohort and altered immune response in vitamin d deficient European-american healthy controls. PLoS One. (2014) e94500.

20. L. Chen, W. Wang, B. Su, Y. Wen, C. Li, Y. Zhou, M. Li, X. Shi, Du H, Y. Song and L. Jiang. A light-responsive release platform by controlling the wetting behavior of hydrophobic surface. ACS Nano. (2014) 744-751.

21. Du H, C. Li, H. Jin, G. Chen and Y. Xun. Generation and evaluation of antibodies against human MGF E-peptide by reverse phase protein micro and reverse competitive ELISA. Bioanalysis. (2013) 2269-2275.

22. L.P. Xu, Y. Liu, J. Zhao, S. Wang, C.S. Lin, R.Q. Zhang, Y. Wen, Du H and X. Zhang. Self-assembly of thiophene derivatives on highly oriented pyrolytic graphite: hydrogen bond effect. J Nanosci Nanotechnol. (2013) 1226-1231.

23. S. Wang, L.P. Xu, Y. Wen, Du H, S. Wang and X. Zhang. Space-confined fabrication of silver nanodendrites and their enhanced SERS activity. Nanoscale. (2013) 4284-4290.

24. X. Liu, P. Lin, X. Yan, Z. Kang, Y. Zhao, Y. Lei, C. Li, H. Du and Y. Zhang, Enzyme-coated single ZnO nanowire FET biosensor for detection of uric acid, Sensors and Actuators B: Chemical 176 (2013) 22-27.

25. Y. Wen, W. Wang, Z. Zhang, L. Xu, Du H, X. Zhang and Y. Song, Controllable and reproducible construction of a SERS substrate and its sensing applications, Nanoscale 5 (2013) 523-526.

26. Du H, G. Chen, S. Wang, S. Wang, S. Li, C. Li, Y. Xun, C. He and M. Wu, Immunological screening and characterization of highly specific monoclonal antibodies against 20 kDa hGH, Bioanalysis 4 (2012) 2161-2168.

27. Y. Wen, L. Xu, C. Li, Du H, L. Chen, B. Su, Z. Zhang, X. Zhang and Y. Song, DNA-based intelligent logic controlled release systems, Chem Commun (Camb) 48 (2012) 8410-8412.

28. H. Dong, J. Zhang, H. Ju, H. Lu, S. Wang, S. Jin, K. Hao, Du H and X. Zhang, Highly sensitive multiple microRNA detection based on fluorescence quenching of graphene oxide and isothermal strand-displacement polymerase reaction, Anal Chem 84 (2012) 4587-4593.

29. Y. Wen, L. Chen, W. Wang, L. Xu, Du H, Z. Zhang, X. Zhang and Y. Song, A flexible DNA modification approach towards construction of gold nanoparticle assemblies, Chem Commun (Camb) 48 (2012) 3963-3965.

30. H. Du, C. Li, G. Chen, H. Jin, T. Hua, S. Li and X. Zhang, Multiple Foreign Gene Delivery Can Induce Antibody Production in Mice, Anal Lett. (2012) 641-644.

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