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河北大學(xué)化學(xué)與環(huán)境科學(xué)學(xué)院研究生導(dǎo)師王書(shū)香介紹如下：

一、個(gè)人簡(jiǎn)介

王書(shū)香, 男, 生于1965年11月，河北省廊坊大城縣人。博士，教授，碩士研究生導(dǎo)師。迄今為止，發(fā)表SCI收錄論文40余篇;獲中國(guó)發(fā)明專(zhuān)利授權(quán)2項(xiàng)，曽主持和參與科研課題多項(xiàng)。2007年度獲河北省科技進(jìn)步三等獎(jiǎng)。2014年獲河北省自然科學(xué)二等獎(jiǎng)。

聯(lián)系方式：E-mail: wsx@hbu.edu.cn

二、主講課程及研究方向

1.主講課程：有機(jī)化學(xué)

2.研究方向：有機(jī)合成、藥物化學(xué)、小分子探針

三、代表性論文

1. Shuxiang Wang*, Wenqing Shao, Hongdong Li, Cui Liu, Ke Wang, Jinchao Zhang*. Synthesis, characterization and cytotoxicity of the gold(III) complexes of 4,5-dihydropyrazole-1-carbothioamide derivatives. Eur J Med Chem., 2011, 46, 1914-1918.

2. Shuxiang Wang, Hongdong Li, Chao Chen, Jinchao Zhang*, Shenghui Li, Xinying Qin, Xiaoliu Li*, Kerang Wang. Cytotoxicity and DNA binding property of phenanthrene imidazole with polyglycol side chains. Bioorg Med Chem Lett., 2012, 22: 6347–6351.

3. Shuxiang Wang*, Yanan Shi, Wenqing Shao, Jianlong Du, Haiying Wei, Jinchao Zhang*, Ke Wang, Shigang Shen, Shenghui Li, Jitai Li and Yangyang Zhao.Synthesis, characterization and cytotoxicity of gold(III) complexes with deprotonated pyridyl carboxamide. Appl. Organometal. Chem. (2012)

4. Yanan Shi, Wenhao Chu, Yuechai Wang, Shuxiang Wang*, Jianlong Du, Jinchao Zhang*, Shenghui Li, Guoqiang Zhou, Xinying Qin, Chenliang Zhang. Synthesis, characterization and cytotoxicity of the Au(III) complexes with cyclic amine-based dithiocarbamate ligands. Inorganic Chemistry

Communications, 2013, 30: 178–181.

5. Shizhu Chen, Yingjian Hou, Gong Cheng, Cuimiao Zhang, Shuxiang Wang*, Jinchao Zhang*. Cerium Oxide Nanoparticles Protect Endothelial Cells from Apoptosis Induced by Oxidative Stress. Biol Trace Elem Res, 2013, 154, 156–166.

6. Shuxiang Wang*, Wenhao Chu, Yuechai Wang, Siyuan Liu, Jinchao Zhang, Shenghui Li, Haiying Wei, Guoqiang Zhou, Xinying Qin. Synthesis, characterization and cytotoxicity of Pt(II), Pd(II), Cu(II) and Zn(II) complexes with 4’-substituted terpyridine. Appl Organometal Chem, 2013, 27, 373–379.

7. Wenhao Chu, Yuechai Wang, Siyuan Liu, Xueyun Yang, Shuxiang Wang*, Shenghui Li, Guoqiang Zhou, Xinying Qin, Chuanqi Zhou, Jinchao Zhang*. Synthesis, cytotoxicity and DNA-binding properties of Pd(II), Cu(II) and Zn(II) complexes with 4¢-(4-(2-(piperidin-1-yl)ethoxy)phenyl)- 2,2’:6’,2’’-terpyridine.

Bioorg Med Chem Lett., 2013, 23: 5187–5191.

8. Cui Liu, Siyuan Liu, Yuechai Wang, Shuxiang Wang*, Jinchao Zhang*, Shenghui Li, Xinying Qin,Xiaoliu Li, Kerang Wang,Quoqiang Zhou. Synthesis, cytotoxicity, and DNA-binding property of berberine derivatives. Med Chem Res, 2014, 23:1899–1907.

9. Shizhu Chen, Cuimiao Zhang, Guang Jia, Jianlei Duan, ShuxiangWang*, Jinchao Zhang*. Size-dependent cytotoxicity of europium doped NaYF4nanoparticles in endothelial cells. Materials Science and Engineering C, 2014, 43: 330–342.

四、科研項(xiàng)目

1.2011.01-2013.12: 主持河北省自然科學(xué)基金：二茂鐵基環(huán)Au(III)化合物的設(shè)計(jì)、合成與抗腫瘤活性研究

2. 2012.01-2014.12: 主持河北省教育廳重點(diǎn)項(xiàng)目：新型Co(III)配合物類(lèi)乏氧激活性抗腫瘤前藥的設(shè)計(jì)、合成與篩選

3. 2015-2017主持河北省應(yīng)用基礎(chǔ)研究計(jì)劃重點(diǎn)基礎(chǔ)研究項(xiàng)目：茚(1,2-b)喹喔啉-5,10-二氧-11-酮肟醚類(lèi)乏氧激活性抗腫瘤前藥的設(shè)計(jì)、合成與抗腫瘤機(jī)制研究

五、授權(quán)專(zhuān)利

1. 發(fā)明人：王書(shū)香，張金超, 李勝輝，秦新英，宋長(zhǎng)英，邵文慶. 具有抗腫瘤活性酰胺類(lèi)Au(III)配合物、制備方法及應(yīng)用. 專(zhuān)利號(hào)：ZL 201110157868.9