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劉  艷   副教授, 碩士生導師

北京大學藥學院藥劑學系副主任

北京市海淀區學院路38號，郵編  100191

Tel: (+8610) 82801508

Email: yanliu@bjmu.edu.cn

1986年在山東大學化學系獲得理學學士學位。1989年在山東大學化學系獲得理學碩士學位。同年8月到北京醫科大學藥學院工作。1998-2000年到德國雷根斯堡大學化學與藥學系工作與學習。2000年至今，任北京大學藥學院藥劑學系副教授。講授物理化學、物理藥劑學和分散體系的物理化學等本科、碩士和博士研究生課程。擔任《化學學報》、《藥學學報》、《中國藥學雜志》、《中國新藥雜志》、International Journal of Pharmaceutics、Biomaterials等多個學術期刊的評審。主持或參加的基金項目包括國家自然科學基金、973重大研究計劃、國家重大新藥創制專項新劑型與新釋藥系統技術平臺等。在國內、外學術期刊上發表論文60余篇。主編教材或專著5部，主譯專著1部，參編教材2部。申請國家發明專利16項。主持完成了數個藥物制劑的研究開發工作。

研究興趣

物理藥劑學。主要涉及以下研究領域

1. 新型納米載體系統與靶向給藥

2. 藥用高分子材料的分子設計、合成與性能評價

3. 藥物多晶型

代表性論文

1. Xiaoning Wang, Xinru Li, Yanxia Zhou, Yan Liu*, et al. Synthesis, characterization and biocompatibility of poly(2-ethyl-2-oxazoline)-poly(D,L-lactide)-poly(2-ethyl-2-oxazoline) hydrogels. Acta Biomaterialia, 2011, 7: 4149-4159.

2. Xinru Li, Yuanting Yue, Yanxia Zhou, Yan Liu*, et al. An oil-free microemulsion for intravenous delivery of diallyl trisulfide: Formulation and evaluation. International Journal of Pharmaceutics, 2011, 407:158-166.

3. Xinru Li, Yanhui Zhang, Yating Fan, Yan Liu*, et al. Preparation and evaluation of novel mixed micelles as nanocarriers for intravenous delivery of propofol. Nanoscale Research Letters, 2011, 6:275.

4. Xingwei Chen, Xinru Li, Yanxia Zhou, Yan Liu*, et al. Chitosan-based thermosensitive hydrogel as a promising ocular drug delivery system: preparation, characterization and in vivo evaluation. Journal of Biomaterials Applications, online on July 12, 2011. doi:10.1177/0885328211406563.

5. Yating Fan, Xinru Li, Yanxia Zhou, Yan Liu*, et al. Improved intestinal delivery of salmon calcitonin by water-in-oil microemulsions. International Journal of Pharmaceutics, 2011, 416:323-330.

6. Yanhui Zhang, Xinru Li, Yanxia Zhou, Yan Liu*, et al. Cyclosporine A-loaded poly(ethylene glycol)-b-poly(D,L-lactic acid)  micelles: preparation, in vitro and in vivo characterization and transport mechanism across the intestinal barrier. Molecular Pharmaceutics, 2010, 7(4):1169-1182.

7. Wang Fei, Li Xinru, Zhou Yanxia, Yan Liu*, et al. Novel nanoscaled polyion complex micelles for targeted delivery of recombinant hirudin to platelets based on cationic copolymer. Molecular Pharmaceutics, 2010, 7(3):718-726.

8. Xinru Li, Pingzhu Li, Yan Liu*, et al. Novel mixed polymeric micelles for enhancing delivery of anticancer drug and overcoming multidrug resistance in tumor cell lines simultaneously. Pharmaceutical Research, 2010, 27(8):1498-1511.

9. Xinru Li, Xiaoyan Li, Yanxia Zhou, Yan Liu*, et al. Development of patch and spray formulations for enhancing topical delivery of   sinomenine hydrochloride. Journal of Pharmaceutical Sciences, 2010, 99(4):1790-1799.

10. Yanhui Zhang, Xinru Li, Yanxia Zhou, Yan Liu*, et al. Preparation and evaluation of poly(ethylene glycol)–poly(Lactide) micelles as nanocarriers for oral Delivery of cyclosporine A. Nanoscale Resrarch Letters, 2010, 5:917-925.

11. Xinru Li, Quan Yuan, Yanqing Huang, Yanxia Zhou, and Yan Liu*. Development of silymarin self-microemulsifying drug delivery system with enhanced oral bioavailability. AAPS PharmSciTech, 2010, 11(2):672-678.

12. Ming Chen , Xin-Ru Li, Yan-Xia Zhou, Yan Liu*, et al. Improved absorption of salmon calcitonin by ultraflexible liposomes  through intranasal delivery. Peptides, 2009,30:1288-1295.

13 Kewei Yang, Xinru Li, Zhuoli Yang, Yan Liu*, et al. Novel polyion complex micelles for liver-targeted delivery of diammonium glycyrrhizinate: in vitro and in vivo characterization. Journal of Biomedical Materials Research Part A, 2009, 87(4):140-148.

14. Xinru Li, Yanqing Huang, Xingwei Chen, Yanxia Zhou, Yan Liu*, et al. Self-assembly and characterization of Pluronic P105 micelles for liver-targeted delivery of silybin. Journal of Drug Targeting, 2009, 17(10):739-750.

15. Xinru Li, Zhuoli Yang, Kewei Yang, Yan Liu*, et al. Self-assembled polymeric micellar nanoparticles as nanocarriers for poorly soluble anticancer drug ethaselen. Nanoscale Resrarch Letters, 2009, 4:1502-1511.

16. Zhuoli Yang, Xinru Li, Kewei Yang, Yan Liu*. Amphotericin B-loaded poly(ethylene glycol)-poly(lactide) micelles: preparation, freeze-drying and in vitro release. Journal of Biomedical Materials Research Part A, 2008, 85(2):539-546.